2-Chloro-N-[2-(3-methoxyphenyl)ethyl]acetamide

2-Chloro-N-[2-(3-methoxyphenyl)ethyl]acetamide - Names and Identifiers

Name	2-Chloro-N-[2-(3-methoxyphenyl)ethyl]acetamide
Synonyms	2-Chloro-N-(m-methoxyphenethyl)acetamide Acetamide, 2-chloro-N-(m-methoxyphenethyl)- 2-Chloro-N-[2-(3-methoxyphenyl)ethyl]acetamide 2-Chloro-N-[2-(3-methoxyphenyl)ethyl]-acetamide 2-CHLORO-N-[2-(3-METHOXYPHENYL)ETHYL]-ACETAMIDE 2-chloro-N-[2-(3-methoxyphenyl)ethyl]ethanamide acetamide, 2-chloro-N-[2-(3-methoxyphenyl)ethyl]-
CAS	34162-12-4
InChI	InChI=1/C11H14ClNO2/c1-15-10-4-2-3-9(7-10)5-6-13-11(14)8-12/h2-4,7H,5-6,8H2,1H3,(H,13,14)

2-Chloro-N-[2-(3-methoxyphenyl)ethyl]acetamide - Physico-chemical Properties

Molecular Formula	C11H14ClNO2
Molar Mass	227.69
Density	1.158±0.06 g/cm3(Predicted)
Boling Point	416.9±35.0 °C(Predicted)
Flash Point	205.9°C
Vapor Presure	3.7E-07mmHg at 25°C
pKa	14.03±0.46(Predicted)
Refractive Index	1.524

2-Chloro-N-[2-(3-methoxyphenyl)ethyl]acetamide - Risk and Safety

Hazard Class

IRRITANT

2-Chloro-N-[2-(3-methoxyphenyl)ethyl]acetamide - Introduction

2-Chloro-N-[2-(3-methoxyphenyl)ethyl]acetamide is an organic compound with the formula C11H14ClNO2, which is a white crystalline solid.

Nature:
-Appearance: White crystalline solid
-Melting point: about 100-102°C
-Solubility: Soluble in organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane, insoluble in water.

Use:
2-Chloro-N-[2-(3-methoxyphenyl)ethyl]acetamide is useful as an intermediate compound for pharmaceutical synthesis.
It can be used to synthesize imidazole compounds and other carboxylic acid activating reagents in organic synthesis reactions.

Preparation Method:
The preparation of 2-Chloro-N-[2-(3-methoxyphenyl)ethyl]acetamide can be carried out by the following steps:
1. 2-chloroacetyl chloride (2-chloroacetyl chloride) was added to methoxyphenethylamine (3-methoxyphenethylamine) in an ice bath.
2. Stir the reaction mixture at room temperature until the reaction is complete.
3. After solvent application and cooling, the product was crystallized and filtered.
4. The product was further purified to give pure 2-Chloro-N-[2-(3-methoxyphenyl)ethyl]acetamide.

Safety Information:
Note the following safety precautions when handling and storing 2-Chloro-N-[2-(3-methoxyphenyl)ethyl]acetamide:
-Avoid direct contact with skin and eyes and use personal protective equipment (e. g. gloves, glasses).
-Operate in a well-ventilated place to avoid inhaling vapors.
-avoid contact with oxidants, strong alkali and other substances.
-Store in a dry, cool place, away from fire and flammable materials.

Last Update：2024-04-09 15:17:56